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Research Facts 5-Amino-1MQ (full name: 5-amino-1-methylquinolinium) is a synthetic small-molecule compound studied for its ability to inhibit nicotinamide N-methyltransferase (NNMT), an enzyme found in elevated levels in white adipose tissue

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NA cannot be salvaged into NAD + any longer if it is N-methylated by NNMT, so the methylation of NA impairs the abundance of free NAD + and then affects the activities of these NAD + -consuming enzymes [19]