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This results in the activation of mast cells and the release of inflammatory mediators, including histamine, leukotrienes, and others, which can manifest as pruritus, urticaria, angioedema, bronchospasm, vomiting, and hypotension

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Retatrutide: Phase 2 data showed A1c reductions of 1.5-2.0%, with the glucagon component adding complexity to blood sugar management