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At the same time, more and more basic studies show that some traditional Chinese medicines or natural products may indirectly affect peripheral immunity and synovial inflammation by regulating the balance of intestinal flora, enhancing the intestinal mucosal barrier, and remodeling the metabolite spectrum ( This review systematically summarizes the evidence of the research on the relationship between traditional Chinese medicine/natural product intervention rheumatoid arthritis (RA) and intestinal microecology from 2015 to 2025