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The Cu(II) center produces a characteristic d-d absorbance band in the visible region, which allows binding stoichiometry, coordination geometry, and stability constants to be determined by UV-Vis spectrophotometry, circular dichroism, electron paramagnetic resonance, and potentiometric titration

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The published research associated with all four compounds sits predominantly in preclinical (in vitro and animal-model) literature, with limited early-phase human investigation reported for some of the parent molecules