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Consequently, folate derivatives such as dihydro, tetrahydro, methyl and formyl forms are expected, invariably conjugated with p-aminobenzoyl-glutamate as mono-, di-, tri- or polyglutamates (36-38)

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Whereas Xpd TTD/TTD mice generally show less exploratory behavior compared to wildtype littermates, FOXO4-DRI treated animals were noticeably more active (Fig