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Activation of estrogen receptors (ERα and ERβ) has been shown to enhance insulin signaling efficiency, improve mitochondrial biogenesis via PGC-1α–related pathways, and promote lipid oxidation in metabolically active tissues [42]

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The synergistic effect of probiotic postbiotics weakening certain defenses (adhesion, matrix, morphology) of multi-species biofilms would ultimately restore access to antifungals as well as potency against the pathogens ( Candida and bacteria on either a mucosal surface or a device surface, are particularly effective in responding to the actions of probiotic filtrates