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Folate is also important in the mitochondria, but those folate-dependent reactions rely on SHMT and 1-formyl-THF instead of MTHFR and methylfolate.[ref] The MTHFR C677T and A1298C variants: Two common variants in the MTHFR gene, C677T and A1298C, cause the enzyme not to function normally
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Note on evidence: this is a review of predominantly in-vitro and animal work, and a broad transcriptional footprint describes scope, not therapeutic benefit
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