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IGF-1, fasting glucose, HbA1c, and a comprehensive metabolic panel are the core markers for evaluating GH axis function and metabolic safety before and during any GHRH analog evaluation

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The acute risks cluster around four effects: Hypoglycemia: IGF-1 is structurally similar to insulin, binds with low affinity to insulin receptors, suppresses hepatic glucose production, and stimulates peripheral glucose utilization, with hypoglycemia risk concentrated in the first month of treatment, according to Drugs.com in 2025