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Among the targets of p53 activity are sestrins (sestrin 1 and 2) that induce the activity of peroxiredoxins, increasing the impact of the cellular antioxidant array 26

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BDNF (brain-derived neurotrophic factor) supports neuronal survival, synaptic plasticity, and learning-associated hippocampal processes, making this the mechanistic through-line most relevant to Semax's cognitive effects