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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Falleti MG, Maruff P, Burman P, and Harris A

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Yes, glutathione can help lighten dark spots — but the effect is gradual, and the results depend on several factors: Cause of pigmentation (acne, melasma, sun damage, post-inflammatory hyperpigmentation) Skin tone and type Duration of use Method of administration Combination with other treatments For example, in cases of melasma or stubborn acne marks, glutathione is most effective when used alongside other therapies such as chemical peels, lasers, and prescription creams