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GSH-activated prodrugs, including disulfide- and diselenide-linked conjugates, are selectively activated in tumors, enabling high drug loading and targeted delivery
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However, a 145-patient randomised controlled trial (RCT) reported that 4 g of paracetamol daily in divided doses for 4 days was associated with an increase in ALT activity in a significant proportion of patients when compared to placebo, although the clinical significance of this elevation in ALT is unclear [24]