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Lactoferrin was also effective in treating pregnant women with iron deficiency anemia: Oral administration of lactoferrin (100 mg/twice a day for 30 days), that was iron-saturated to 30%, increased the total serum iron and hemoglobin concentrations to a greater extent than administration of ferrous sulphate (156 mg/day) in 60 anemic women (Paesano et al., 2009, 2010)

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The designation is based on the FDA’s determination that these compounds present “risk for immunogenicity, peptide-related impurities, and limited safety-related information.” For the full regulatory breakdown, see our FDA peptide regulations guide