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SOCS1 directly inhibits the catalytic activity of JAK1, JAK2, and Tyrosine kinase 2 (TYK2), but not of JAK3, while SOCS3 is recruited by cytokine receptors that contain high-affinity SOCS3 binding sites (such as glycoprotein (gp)130, LeptinR, granulocyte colony-stimulating factor receptor (GCSFR), etc.)