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The cost scoring methodology we finalized at § 414.1380(b)(2) is now based on standard deviation, median, and an achievement point value that is derived from the performance threshold

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Liver fibrosis is a key marker of MASLD/MASH progression, initiated by elevated hepatocyte expression of pro-fibrotic TFs such as Sox9 and secreted factors such as Spp1 (osteopontin) and Tgfb1 (TGF-β1)