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Common symptoms of Hashimoto’s include: Chronic fatigue that doesn’t improve with rest or sleep Unexplained weight gain , even with regular diet and exercise Hair thinning or hair loss , especially at the crown or outer eyebrows Cold intolerance or feeling cold when others are comfortable Constipation and slower digestion Brain fog and trouble with memory, focus, or concentration Depression or low mood that seems hormonal but persists Dry skin and brittle nails Menstrual irregularities or heavier-than-normal periods Puffy face or swelling in the neck (enlarged thyroid or goiter) These symptoms may worsen or change during menopause , especially as estrogen and progesterone decline