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It was showed that NP4 treatment leaded to an increase in pro-inflammatory M1-type macrophages and a decrease in anti-inflammatory M2-type macrophages in mouse tumor tissues, with the proportion of M1 to M2 macrophages being 4.4 times higher compared to untreated mouse tumor tissues (Fig

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Isotype control antibody (Green line) was rabbit IgG (1 μg/1x10 6 ) used under the same conditions