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Key Pathobiology Relevant to Regeneration Disc dehydration, inflammation, and matrix breakdown are central pathological processes in lumbar disc degeneration (LDD), each critically influencing the potential for regeneration and the efficacy of emerging biologic therapies

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Tralokinumab-ldrm and nemolizumab can cause other side effects like upper respiratory tract infections (such as the common cold) and high levels of eosinophils (a type of white blood cell)