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The patient did experience disease progression again after 24 months of monotherapy

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There can be an immediate solution, along with its modulatory controlling effect described above for VEGF (see above, Section 2.3 and Section 2.4), as the promoter of the egr-1 gene also mediates angiogenesis [158,159] and induces cytokine and growth factor generation and early extracellular matrix (collagen) formation