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Ubiquitin substrate overcomes C-degron mimic autoinhibition of WT oligomeric KLHDC3 We previously showed that KLHDC2 and KLHDC3 are subject to C-degron-mimic mediated self-assembly 35 : the C-terminal Gly-Ser or His-Gly motifs from one KLHDC2 or KLHDC3 protomer, respectively, occupies the substrate-binding site of the adjacent protomer in a tetrameric assembly (Fig
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