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FDA's statement on unapproved GLP-1 drugs (content current as of September 1, 2026) says retatrutide cannot be used in compounding under federal law, that it has not been found safe and effective for any condition, and that the agency has issued warning letters to telehealth companies marketing it, to distributors selling the ingredient, and to sellers labeling it for research use only

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The review found improved structural, functional, and biomechanical outcomes across injury types