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If stomach acid levels are low, whether due to age, certain medications (like proton pump inhibitors), or digestive issues, B12 might not be properly released

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Bottle Size:100 mL

Why oral absorption fails, since it is not a formulation problem that better capsules would fix: the same study reports the compound is highly soluble — over 100 mg/mL in phosphate-buffered saline and over 10 mg/mL in simulated gastric fluid — and barely binds plasma protein (7%)