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Aquaporin-4 (AQP4), predominantly expressed in astrocytic end-feet, regulates the flux of cerebrospinal fluid, clearance of amyloid-beta, and inflammation [57, 58]
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TB-500 has been examined in brain injury and neurodegeneration models — with research documenting neuronal cell survival promotion through PI3K/Akt anti-apoptotic signalling, promotion of neurogenesis and oligodendrocyte progenitor migration following white matter injury, and anti-inflammatory effects in the injured CNS
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