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Elevated nitric oxide (NO), reactive oxygen species (ROS), and pro-inflammatory cytokines (IL-1β, TNF-α, IFN-γ) further inhibit SLC7A11 and destabilize GPX4 activity in cancer cells

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Recent metanalysis have revealed significant increase in oxidative stress markers such as MDA and a substantial depletion of antioxidants such as catalase, GSH in the blood, and postmortem brain of PD patients compared to healthy controls 25