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For example, DJ-1 has been proposed to function as a regulator of the 20S proteasome 3,4,5 , a chaperone for alpha-synuclein 6 , a regulator of the androgen receptor 7 , a redox-sensitive esterase 8 , a peroxiredoxin-like peroxidase that scavenges H 2 O 2 9 , a transcriptional regulator 10 , an RNA binding protein 11 , a regulator of tyrosine hydroxylase 12 , a protease 13 , a stabilizer of the antioxidant transcriptional regulator Nrf2 14 , a regulator of Bax 15 , and a transcriptional regulator of uncoupling (UCP) proteins 16

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