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Likewise, there are inhibited the mRNA of inflammatory mediators ( iNOS , IL-6, IFNγ, and TNF-α), increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi [5]

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The rat model does not fully replicate the complexity of human PAD, thereby limiting clinical translation