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Abstract Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remains a challenging chronic disorder with complex pathophysiology and limited therapeutic options

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The role of traditional medicine in regulating tight junction proteins was also evidenced by many other studies, such as the study by ( Bryophyllum pinnatum (Lamarck) Leaf (BPL), a medicinal plant widely used in traditional medicine in Brazil for treating inflammatory diseases, was at least partially due to its regulation of ZO-1