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For patients without neurological involvement , hydroxocobalamin 1 mg is administered intramuscularly three times a week for 2 weeks, followed by maintenance injections every three months for life (if due to pernicious anaemia or other non-dietary cause)
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Even following an extended period of automated continuous evolution, DEP strains consistently demonstrated a complete absence of observable escape events and maintained effective containment without causing detrimental effects upon introduction into mammalian cell cultures
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