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H 2 O 2 and O 2 • − activate stress-sensitive serine/threonine kinases such as JNK, IKKβ, and PKCθ, which phosphorylate IRS-1 at inhibitory serine residues (Ser307, Ser612), disrupting its interaction with the insulin receptor and promoting proteasomal degradation (Roden et al., 2017)
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