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Structurally, tesamorelin is GHRH(1–44) modified with a trans-3-hexenoic acid group that extends its plasma half-life from minutes to approximately 30–38 minutes — more stable than native GHRH, but still requiring daily subcutaneous injection

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Circulating tumor DNA (ctDNA) as an early marker to monitor clinical benefit of regorafenib and TAS-102 in patients with metastatic colorectal cancer (mCRC)