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The clinical features of Se toxicity mainly include brittle hair and nail loss, gastrointestinal disorders, rash, rickets and neurological disorders (116)
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Research has shown GHK-Cu influences expression of over 4,000 human genes, stimulates collagen I, III and elastin synthesis, activates matrix metalloproteinases for extracellular matrix remodelling, supports angiogenesis through VEGF and FGF upregulation, and suppresses pro-inflammatory TNF-α signalling
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