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Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief

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“However, we do not fully understand why these aging hallmarks occur in the first place, and therefore there have been no proven solutions via human randomized clinical trials to improve or correct aging hallmarks in aging humans