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In this regard, there exist some investigations addressing transient relaxing of TJ regulation by means of osmotic22 or biologically active agents (e.g., bradykinin, cereport and histamine), 23-25 (b) transcellular passive diffusion that is a primary route for small lipophilic substances, which could be optimized by altering drug physicochemical properties, (c) SLC-mediated transport exploiting the diverse members of the SLC family of transporters preset within the BBB (e.g., various amino acids), 8,26 (d) endocytosis through RMT (e.g., monoclonal antibodies (mAbs) specific to various receptors at the BBB like Tf receptor, targeted nanomedicines), 27-29 and (e) adsorptive endocytosis or pinocytosis (e.g., albumin) a relatively low capacity route with non-receptor bound material shuttled to the lysosomes for degradation
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& Finnell, J
