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By binding copper(II) ions, it helps regulate gene expression linked to collagen formation, angiogenesis, antioxidant defense, and tissue remodeling.⁴ ⁵ ⁶ ⁷ The peptide’s small size allows it to penetrate tissues efficiently, and its copper-transfer activity underlies its reported effects on skin, hair, and wound-healing processes in laboratory models
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The Pit-1 t transcription factor determines the specific cellular expression of GH (and also prolactin (PRL) and thyroid-stimulating hormone (TSH))
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