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The consequence Kraus proposed for the SAM half of the story is polyamine flux: more SAM means more substrate for ornithine decarboxylase and spermidine-spermine N1-acetyltransferase, and the futile polyamine synthesis and catabolism cycle those enzymes drive consumes ATP, raising oxygen consumption in adipocytes without any change in food intake
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Long-term effects, rare adverse reactions, and interactions with other medications or conditions – these critical safety questions remain unanswered
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